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EMCCDs Article Electron Multiplying Charge-Coupled Devices (EMCCDs)

By incorporating on-chip multiplication gain, the electron multiplying CCD achieves, in an all solid-state sensor, the single-photon detection sensitivity typical of intensified or electron-bombarded CCDs at much lower cost and without compromising the quantum efficiency and resolution characteristics of the conventional CCD structure.

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Mitochondria in Fibroblast Cells

Objective: UPlanSApo 100x oil/1.40 Exposure: 500 ms
Microscope: Olympus DSU/IX81 Gain: 3
Camera: Hamamatsu ImagEM Interval: 2 s

Depending upon the metabolic requirements of an organism, a cell can contain between one and many thousands of mitochondria. First discovered with a light microscope in the 1800s, these large organelles are found in almost all eukaryotes: plants, animals, protists, and even fungi. Because of the way they appear under the microscope, the scientists who first observed them called them mito-chondria after the Greek words for “thread” and “granules” respectively. A method of isolating the organelles without damaging them was developed around the 1950s, which lead to our current understanding of the functioning of the mitochondrion. The digital video above displays normal lung fibroblast cells (FoLu line) from the Gray fox expressing monomeric green fluorescent protein (mEGFP) that has been fused to the mitochondrial targeting signal from subunit VIII of human cytochrome C oxidase.