Explore Button

Image Galleries

Featured Article

EMCCDs Article Electron Multiplying Charge-Coupled Devices (EMCCDs)

By incorporating on-chip multiplication gain, the electron multiplying CCD achieves, in an all solid-state sensor, the single-photon detection sensitivity typical of intensified or electron-bombarded CCDs at much lower cost and without compromising the quantum efficiency and resolution characteristics of the conventional CCD structure.

Product Information

Digital Video Gallery

Microtubule EB3 in HeLa Cells

Objective: UPlanSApo 100x oil/1.40 Exposure: 250 ms
Microscope: Olympus DSU/IX81 Gain: 3
Camera: Hamamatsu ImagEM Interval: 500 ms

The units responsible for structural support and cellular transport are the microtubules. Microtubules are tiny tubes that are 25 nanometers in diameter and essential to the cytoskeletal structure that gives the cell its form and shape. These versatile organelles also act as conveyer belts moving enzymes and other organelles throughout the cytoplasm. The construction of cilia, flagella, and spindle fibers associated with cell division (mitosis) are all dependent on microtubules. Microtubules change shape and size according to the needs of the cell and its life cycle. The digital video above illustrates the tracking of microtubule +TIPs (plus end tracking proteins) in human cervical carcinoma (HeLa line) epithelial cells labeled with a chimera of EB3 fused to mEGFP.