Image Galleries
Featured Article
Electron Multiplying Charge-Coupled Devices (EMCCDs)
By incorporating on-chip multiplication gain, the electron multiplying CCD achieves, in an all solid-state sensor, the single-photon detection sensitivity typical of intensified or electron-bombarded CCDs at much lower cost and without compromising the quantum efficiency and resolution characteristics of the conventional CCD structure.
Product Information
Digital Video Gallery
Microtubule EB3 in HeLa Cells
 Objective: UPlanSApo 100x oil/1.40 |
Exposure: 250 ms |
| Microscope: Olympus DSU/IX81 |
Gain: 3 |
| Camera: Hamamatsu ImagEM |
Interval: 500 ms |
A variety of microtubule binding proteins, including a family of end-binding proteins (EBs), have been demonstrated to associate specifically with the ends of growing microtubules in a variety of cell types. These proteins are believed to regulate microtubule dynamics and the binding of microtubules to organelles, membrane components, and other protein complexes. The digital video above illustrates the tracking of microtubule +TIPs (plus end tracking proteins) in human cervical carcinoma (HeLa line) epithelial cells labeled with a chimera of EB3 fused to mEGFP.