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EMCCDs Article Electron Multiplying Charge-Coupled Devices (EMCCDs)

By incorporating on-chip multiplication gain, the electron multiplying CCD achieves, in an all solid-state sensor, the single-photon detection sensitivity typical of intensified or electron-bombarded CCDs at much lower cost and without compromising the quantum efficiency and resolution characteristics of the conventional CCD structure.

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ORCA-R2 Digital Video Gallery

Rabbit Kidney (RK-13) Cells with mApple-H2B and mEmerald C-Src

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The C-Src gene is closely related to the viral-sarcoma gene (V-SRC) present in certain cancer-causing retroviruses. The normal cellular gene, C-Src, was first discovered in chickens in the late 1970s by American scientists J. Michael Bishop and Harold E. Varmus. Its detection marked a tremendous breakthrough in cancer research and triggered a major shift in the modern understanding of the disease. Before the discovery, cancer was generally believed to result from invasion by a viral gene foreign to normal cells, but the existence of C-Src demonstrated that a gene normally present in the cells themselves can induce tumors. In the digital video sequences presented in this section, C-Src is fluorescently labeled with m-Emerald and H2B is shown tagged with mApple.