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EMCCDs Article Electron Multiplying Charge-Coupled Devices (EMCCDs)

By incorporating on-chip multiplication gain, the electron multiplying CCD achieves, in an all solid-state sensor, the single-photon detection sensitivity typical of intensified or electron-bombarded CCDs at much lower cost and without compromising the quantum efficiency and resolution characteristics of the conventional CCD structure.

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ORCA-R2 Digital Video Gallery

Human Osteosarcoma Epithelial (U2OS) Cells with mApple-H2B and mEmerald C-Src

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The term Src, an abbreviated form of the word sarcoma, denotes a family of tyrosine kinases that are proto-oncogenic. Generally animal cells contain at least one of the Src families of tyrosine kinases, the enzymes that are able to transfer a phosphate group from ATP to a tyrosine residue. The phosphorylation of proteins by tyrosine kinases is crucial for signal transduction in multicellular animals. V-Src is the mutated version of cellular Src (C-Src) that has lost its characteristic ability to inhibit enzyme activity. C-Src was targeted in the human osteosarcoma epithelial cells featured in the digital video sequences presented in this section with mEmerald, while H2B was fluorescently labeled with mApple.