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EMCCDs Article Electron Multiplying Charge-Coupled Devices (EMCCDs)

By incorporating on-chip multiplication gain, the electron multiplying CCD achieves, in an all solid-state sensor, the single-photon detection sensitivity typical of intensified or electron-bombarded CCDs at much lower cost and without compromising the quantum efficiency and resolution characteristics of the conventional CCD structure.

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ORCA-R2 Digital Video Gallery

Human Osteosarcoma Epithelial (U2OS) Cells with mCherry H2B and mEmerald C-SRC

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An abbreviated form of the word sarcoma, the term Src encompasses a family of tyrosine kinases that are proto-oncogenic. Tyrosine kinases are enzymes that are capable of transferring a phosphate group from ATP to a tyrosine residue. The phosphorylation of proteins by tyrosine kinases is critical for signal transduction in multicellular animals. Generally animal cells contain at least one of the Src families of tyrosine kinases. V-Src is the mutated version of cellular Src (C-Src) that has lost its characteristic ability to inhibit enzyme activity. C-Src was targeted in the fox lung cells featured in the digital video sequences presented in this section with mEmerald, while H2B was fluorescently labeled with mCherry.