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EMCCDs Article Electron Multiplying Charge-Coupled Devices (EMCCDs)

By incorporating on-chip multiplication gain, the electron multiplying CCD achieves, in an all solid-state sensor, the single-photon detection sensitivity typical of intensified or electron-bombarded CCDs at much lower cost and without compromising the quantum efficiency and resolution characteristics of the conventional CCD structure.

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ORCA-R2 Digital Video Gallery

Human Osteosarcoma Epithelial (U2OS) Cells with mEmerald alpha-Actinin and mCherry-Farnesyl

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Due to their interaction with the microfilament actin, members of the cross-linking and bundling protein family known as alpha-actinin are popular targets for fluorescently tagging the cytoskeletal actin network. In non-muscle cells, alpha-actinin proteins are usually sensitive to calcium, whereas in muscle cells the proteins typically exhibit insensitivity to calcium. In the digital video sequences presented in this section, alpha-actinin was targeted with mEmerald. The U2OS cells were also labeled with mCherry fused to farnesyl.