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EMCCDs Article Electron Multiplying Charge-Coupled Devices (EMCCDs)

By incorporating on-chip multiplication gain, the electron multiplying CCD achieves, in an all solid-state sensor, the single-photon detection sensitivity typical of intensified or electron-bombarded CCDs at much lower cost and without compromising the quantum efficiency and resolution characteristics of the conventional CCD structure.

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ORCA-R2 Digital Video Gallery

Human Osteosarcoma Epithelial (U2OS) Cells with mEmerald C-Src and mCherry-Lifeact

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Microfilaments were visualized in the human bone osteosarcoma cells featured in the digital video sequences in this section with mCherry fused to Lifeact. Also known as actin filaments, microfilaments are usually nucleated at the plasma membrane, unlike microtubules, which typically extend from centrosomes. Thus the cell periphery is generally the cellular region containing the highest concentration of microfilaments. A variety of external factors, however, and a collection of specialized proteins strongly influence the characteristics of microfilaments. C-Src was also targeted in the featured cells with mCherry, one of the red members of the "mFruit" family of fluorescent proteins.